CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions.

ABSTRACT: Classical cadherins and their connections with microtubules (MTs) are emerging as important determinants of cell adhesion. However, the functional relevance of such interactions and the molecular players that contribute to tissue architecture are still emerging. In this paper, we report that the MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes. Reductions in the levels of p120 or CLASP2 decreased the localization of the other protein to cell-cell contacts and altered AJ dynamics and stability. These features were accompanied by decreased MT density and altered MT dynamics at intercellular junction sites. Interestingly, CLASP2 was enriched at the cortex of basal progenitor keratinocy

SUBMITTER: Shahbazi MN 

PROVIDER: S-EPMC3871427 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature