Pro-surfactant protein B as a biomarker for lung cancer prediction.

ABSTRACT:

Purpose

Preliminary studies have identified pro-surfactant protein B (pro-SFTPB) to be a promising blood biomarker for non-small-cell lung cancer. We conducted a study to determine the independent predictive potential of pro-SFTPB in identifying individuals who are subsequently diagnosed with lung cancer.

Patients and methods

Pro-SFTPB levels were measured in 2,485 individuals, who enrolled onto the Pan-Canadian Early Detection of Lung Cancer Study by using plasma sample collected at the baseline visit. Multivariable logistic regression models were used to evaluate the predictive ability of pro-SFTPB in addition to known lung cancer risk factors. Calibration and discrimination were evaluated, the latter by an area under the receiver operating characteristic curve (AUC). Exte

SUBMITTER: Sin DD 

PROVIDER: S-EPMC3871515 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature