The effects of industry sponsorship on comparator selection in trial registrations for neuropsychiatric conditions in children.

ABSTRACT: Pediatric populations continue to be understudied in clinical drug trials despite the increasing use of pharmacotherapy in children, particularly with psychotropic drugs. Most pertinent to the clinical selection of drug interventions are trials directly comparing drugs against other drugs. The aim was to measure the prevalence of active drug comparators in neuropsychiatric drug trials in children and identify the effects of funding source on comparator selection. We analyzed the selection of drugs and drug comparisons in clinical trials registered between January 2006 and May 2012. Completed and ongoing interventional trials examining treatments for six neuropsychiatric conditions in children were included. Networks of drug comparisons for each condition were constructed using information

SUBMITTER: Dunn AG 

PROVIDER: S-EPMC3871546 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature