Positive association between GCKR rs780093 polymorphism and coronary heart disease in the aged Han Chinese.

ABSTRACT:

Objective

Previous studies have confirmed that GCKR rs780093 polymorphism is associated with triglyceride (TG), a known risk factor of coronary heart disease (CHD). The goal of our study is to explore the association of GCKR rs780093 polymorphism with CHD in Han Chinese population.

Methods and results

A total of 568 CHD cases and 494 non-CHD controls were enrolled in the current case-control study. Genotyping was done using melting temperature shift (Tm-shift) approach. Our results also showed that GCKR rs780093 polymorphism was significantly associated with TG level (P = 0.0016). Although there was no significant association between cases and controls (P > 0.05), a breakdown analysis by age yielded a significant association of GCKR rs780093 polymorphism with CHD in individu

SUBMITTER: Lian J 

PROVIDER: S-EPMC3871702 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature