The natural history of influenza infection in the severely immunocompromised vs nonimmunocompromised hosts.

ABSTRACT:

Introduction

Medical advances have led to an increase in the world's population of immunosuppressed individuals. The most severely immunocompromised patients are those who have been diagnosed with a hematologic malignancy, solid organ tumor, or who have other conditions that require immunosuppressive therapies and/or solid organ or stem cell transplants.

Materials and methods

Medically attended patients with a positive clinical diagnosis of influenza were recruited prospectively and clinically evaluated. Nasal washes and serum were collected. Evaluation of viral shedding, nasal and serum cytokines, clinical illness, and clinical outcomes were performed to compare severely immunocompromised individuals to nonimmunocompromised individuals with influenza infection.

Results</

SUBMITTER: Memoli MJ 

PROVIDER: S-EPMC3871797 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature