Synthesis of nitric oxide probes with fluorescence lifetime sensitivity.

ABSTRACT: We present the rationale, synthesis and evaluation of the first activatable fluorescent probe that utilizes fluorescence lifetime change for detection of nitric oxide. The new probe DAP-LT1 features a near-infrared polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.

SUBMITTER: Zhegalova NG 

PROVIDER: S-EPMC3872128 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature