Robust estimates of divergence times and selection with a poisson random field model: a case study of comparative phylogeographic data.

ABSTRACT: Mutation frequencies can be modeled as a Poisson random field (PRF) to estimate speciation times and the degree of selection on newly arisen mutations. This approach provides a quantitative theory for comparing intraspecific polymorphism with interspecific divergence in the presence of selection and can be used to estimate population genetic parameters. Although the original PRF model has been extended to more general biological settings to make statistical inference about selection and divergence among model organisms, it has not been incorporated into phylogeographic studies that focus on estimating population genetic parameters for nonmodel organisms. Here, we modified a recently developed time-dependent PRF model to independently estimate genetic parameters from a nuclear and mitochond

SUBMITTER: Amei A 

PROVIDER: S-EPMC3872187 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature