Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy: a novel strategy in drug development.

ABSTRACT: Cancer is a leading cause of mortality worldwide and matters are only set to worsen as its incidence continues to rise. Traditional approaches to combat cancer include improved prevention, early diagnosis, optimized surgery, development of novel drugs, and honing regimens of existing anti-cancer drugs. Although discovery and development of novel and effective anti-cancer drugs is a major research area, it is well known that oncology drug development is a lengthy process, extremely costly and with high attrition rates. Furthermore, those drugs that do make it through the drug development mill are often quite expensive, laden with severe side-effects and unfortunately, to date, have only demonstrated minimal increases in overall survival. Therefore, a strong interest has emerged to identify

SUBMITTER: Stenvang J 

PROVIDER: S-EPMC3872326 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature