Fetal growth restriction promotes physical inactivity and obesity in female mice.

ABSTRACT:

Background

Environmental exposures during critical periods of prenatal and early postnatal life affect the development of mammalian body weight regulatory mechanisms, influencing lifelong risk of obesity. The specific biological processes that mediate the persistence of such effects, however, remain poorly understood.

Objective

The objectives of this study were to determine the developmental timing and physiological basis of the obesity-promoting effect previously reported in offspring of obese agouti viable yellow (A(vy)/a) mothers.

Design

Newborn offspring of obese A(vy)/a and lean (a/a) mothers were cross-fostered shortly after birth to study separately the effects of in utero or suckling period exposure to A(vy)/a dams. Body composition, food intake, physical acti

SUBMITTER: Baker MS 

PROVIDER: S-EPMC3872504 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature