Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters.

ABSTRACT: This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of cell tracking and therapies.

SUBMITTER: Clay N 

PROVIDER: S-EPMC3872536 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature