Septo-optic dysplasia complex: Clinical and radiological manifestations in Omani children.

ABSTRACT:

Background

Septo-optic dysplasia (SOD), also known as de-Morsier's syndrome, is a rare disorder characterized by any combination of optic nerve hypoplasia (ONH), pituitary gland hypoplasia, and midline abnormalities of the brain including absence of septum pellucidum and corpus callosum dysgenesis. It is typically diagnosed in infancy and has a variable presentation that includes visual, neurologic, and/or hypothalamic-pituitary endocrine deficits.

Purpose

To demonstrate the ophthalmic, endocrine, and neurologic spectrum of SOD in five Omani children and address the crucial role of high-resolution neuroimaging for its early and accurate diagnosis.

Materials and methods

A retrospective chart review was performed in 2010 of all children in the pediatric ophthalmology da

SUBMITTER: Al-Senawi R 

PROVIDER: S-EPMC3872571 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature