The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives.

ABSTRACT:

Objective

To study the relationship between functional variants in the serotonin transporter gene (SLC6A4) and selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction.

Methods

One hundred fifteen subjects aged 18-40 years and currently being treated with an SSRI for depression were assessed for clinical variables known to affect sexual well-being. SSRI-associated sexual difficulties were assessed with the Changes in Sexual Functioning Questionnaire (CSFQ). Subjects were subsequently genotyped for the SLC6A4 promoter region (5HTTLPR) insertion/deletion variant and a variable number of tandem repeats (VNTR) in the second intron.

Results

The 5HTTLPR insertion/deletion variant was associated with sexual dysfunction in this study sample [odds ratio (OR)

SUBMITTER: Bishop JR 

PROVIDER: S-EPMC3872961 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature