Karlotoxin synthetic studies: concise synthesis of a C(42-63) B-ring tetrahydropyran fragment.

ABSTRACT: Starting from natural D-mannose, a C(42-63) B-ring tetrahydropyran fragment in karlotoxin 2 has been prepared via a common THP intermediate in a concise manner. E-selective Julia-Kocienski olefination efficiently assembled a C(51-63) chlorodiene subunit and a C(42-50) tetrahydropyran segment.

SUBMITTER: Tomioka T 

PROVIDER: S-EPMC3873160 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature