The effect of peritoneal fluid from patients with endometriosis on mitochondrial function and development of early mouse embryos.

ABSTRACT:

Background

Peritoneal fluid (PF) from patients with endometriosis can inhibit early embryo development via probable functional changes of embryo mitochondria in the early stage of embryo development. The purpose of this study was to determine the effect of PF from patients with endometriosis on mitochondrial function and development of early mouse embryos.

Methodology/principal findings

PF was collected from patients with infertility and endometriosis, infertility due to tubal factors, and normal control subjects, and the level of NO was measured. Early murine embryos were then cultured with PF from normal control subjects, those with endometriosis, and with human tubal fluid (HTF), respectively. Cleavage and blastulation rates, mitochondrial DNA (mtDNA) copy numbers, adenos

SUBMITTER: Shu J 

PROVIDER: S-EPMC3873265 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature