Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ABSTRACT:

Background

Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the adult heart experimentally. Moreover, whether these Ca(2+) release channels are present and play a critical role in human cardiomyocytes remains to be defined. IP3Rs may be activated after Gαq-protein-coupled receptor stimulation, affecting Ca(2+) cycling, enhancing myocyte performance, and potentially favoring an increase in the incidence of arrhythmias.

Methods and results

IP3R function was determined in human left ventricular myocytes, and this analysis was integrated with assays in mouse myocytes to identify the mechanisms by which IP3Rs influence the electric and mechanical properties of the myocardium. We report that IP3Rs are expressed and operative in human left ven

SUBMITTER: Signore S 

PROVIDER: S-EPMC3873649 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature