Transcriptome analysis of injured human meniscus reveals a distinct phenotype of meniscus degeneration with aging.

ABSTRACT:

Objective

Meniscus tears are associated with a heightened risk of osteoarthritis. This study aimed to advance our understanding of the metabolic state of injured human meniscus at the time of arthroscopic partial meniscectomy through transcriptome-wide analysis of gene expression in relation to the patient's age and degree of cartilage chondrosis.

Methods

The degree of chondrosis of knee cartilage was recorded at the time of meniscectomy in symptomatic patients without radiographic osteoarthritis. RNA preparations from resected menisci (n = 12) were subjected to transcriptome-wide microarray and QuantiGene Plex analyses. Variations in the relative changes in gene expression with age and chondrosis were analyzed, and integrated biologic processes were investigated computation

SUBMITTER: Rai MF 

PROVIDER: S-EPMC3873730 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature