Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors.

ABSTRACT: Though xenografts are used extensively for drug development in breast cancer, how well xenografts reflect the breadth of primary breast tumor subtypes has not been well characterized. Moreover, few studies have compared the gene expression of xenograft tumors to the primary tumors from which they were derived. Here we investigate whether the ability of human breast tumors (n = 20) to create xenografts in immune-deficient mice is associated with breast cancer immunohistochemical (IHC) and intrinsic subtype. We also characterize how precisely the gene expression of xenografts reprises that of parent breast tumors, using hierarchical clustering and other correlation-based techniques applied to Agilent 44K gene expression data from 16 samples including four matched primary tumor-xenograft pair

SUBMITTER: Petrillo LA 

PROVIDER: S-EPMC3873871 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature