Widespread molecular patterns associated with drug sensitivity in breast cancer cell lines, with implications for human tumors.

ABSTRACT:

Background

Recent landmark studies have profiled cancer cell lines for molecular features, along with measuring the corresponding growth inhibitory effects for specific drug compounds. These data present a tool for determining which subsets of human cancer might be more responsive to particular drugs. To this end, the NCI-DREAM-sponsored DREAM7: Drug Sensitivity Prediction Challenge (sub-challenge 1) set out to predict the sensitivities of 18 breast cancer cell lines to 31 previously untested compounds, on the basis of molecular profiling data and a training subset of cell lines.

Methods and results

With 47 teams submitting blinded predictions, team Creighton scored third in terms of overall accuracy. Team Creighton's method was simple and straightforward, incorporated multi

SUBMITTER: Creighton CJ 

PROVIDER: S-EPMC3873899 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature