Ontology highlight
ABSTRACT:
SUBMITTER: Girardot M
PROVIDER: S-EPMC3874197 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Girardot Michael M Hirasawa Ryutaro R Kacem Salim S Fritsch Lauriane L Pontis Julien J Kota Satya K SK Filipponi Doria D Fabbrizio Eric E Sardet Claude C Lohmann Felix F Kadam Shilpa S Ait-Si-Ali Slimane S Feil Robert R
Nucleic acids research 20131003 1
Symmetrical dimethylation on arginine-3 of histone H4 (H4R3me2s) has been reported to occur at several repressed genes, but its specific regulation and genomic distribution remained unclear. Here, we show that the type-II protein arginine methyltransferase PRMT5 controls H4R3me2s in mouse embryonic fibroblasts (MEFs). In these differentiated cells, we find that the genome-wide pattern of H4R3me2s is highly similar to that in embryonic stem cells. In both the cell types, H4R3me2s peaks are detect ...[more]