IL-33 independently induces eosinophilic pericarditis and cardiac dilation: ST2 improves cardiac function.

ABSTRACT:

Background

IL-33 through its receptor ST2 protects the heart from myocardial infarct and hypertrophy in animal models but, paradoxically, increases autoimmune disease. In this study, we examined the effect of IL-33 or ST2 administration on autoimmune heart disease.

Methods and results

We used pressure-volume relationships and isoproterenol challenge to assess the effect of recombinant (r) IL-33 or rST2 (eg, soluble ST2) administration on the development of autoimmune coxsackievirus B3 myocarditis and dilated cardiomyopathy in male BALB/c mice. The rIL-33 treatment significantly increased acute perimyocarditis (P=0.006) and eosinophilia (P=1.3×10(-5)), impaired cardiac function (maximum ventricular power, P=0.0002), and increased ventricular dilation (end-diastolic volume, P=

SUBMITTER: Abston ED 

PROVIDER: S-EPMC3874395 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature