Effect of hypolipidemic treatment on glycemic profile in patients with mixed dyslipidemia.

ABSTRACT:

Aim

To assess the effect of different hypolipidemic treatment strategies on glycemic profile in mixed dyslipidemia patients.

Methods

This is a prespecified analysis of a prospective, randomized, open-label, blinded end point (PROBE) study (ClinicalTrials.gov identifier: NCT01010516). Patients (n = 100) with mixed dyslipidemia on a standard statin dose who had not achieved lipid targets were randomized to switch to the highest dose of rosuvastatin (40 mg/d) or to add-on-statin extended release nicotinic acid (ER-NA)/laropiprant (LRPT) or to add-on-statin micronised fenofibrate for a total of 3 mo. Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR) index and lipid profile were evaluated at baseline and 3

SUBMITTER: Kei A 

PROVIDER: S-EPMC3874497 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature