Complement factor B polymorphism (rs641153) and susceptibility to age-related macular degeneration: evidence from published studies.

ABSTRACT:

Aim

To determine whether single nucleotide polymorphism (SNP) rs641153 is associated with the risk of age-related macular degeneration (AMD), we performed a systematic meta-analysis of 15 eligible studies. SNP in the complement factor B (CFB) gene is considered to have significant association with AMD susceptibility, but there is great discrepancy in these results.

Methods

The eligible studies were identified by searching the databases of PubMed, EMBASE, and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association. All data were analyzed using Stata software.

Results

The association between rs641153 and AMD risk was statistically significant under the homozygous model (AA vs GG:OR=0.26, 95%CI=0.15-0.45, P h=0.973, I (2)

SUBMITTER: Wang X 

PROVIDER: S-EPMC3874529 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature