HOXB1 restored expression promotes apoptosis and differentiation in the HL60 leukemic cell line.

ABSTRACT:

Background

Homeobox (HOX) genes deregulation has been largely implicated in the development of human leukemia. Among the HOXB cluster, HOXB1 was silent in a number of analyzed acute myeloid leukemia (AML) primary cells and cell lines, whereas it was expressed in normal terminally differentiated peripheral blood cells.

Methods

We evaluated the biological effects and the transcriptome changes determined by the retroviral transduction of HOXB1 in the human promyelocytic cell line HL60.

Results

Our results suggest that the enforced expression of HOXB1 reduces cell growth proliferation, inducing apoptosis and cell differentiation along the monocytic and granulocytic lineages. Accordingly, gene expression analysis showed the HOXB1-dependent down-regulation of some tumor pro

SUBMITTER: Petrini M 

PROVIDER: S-EPMC3874656 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature