Enantio- and regioselective CuH-catalyzed hydroamination of alkenes.

ABSTRACT: A highly enantio- and regioselective copper-catalyzed hydroamination reaction of alkenes has been developed using diethoxymethylsilane and esters of hydroxylamines. The process tolerates a wide variety of substituted styrenes, including trans-, cis-, and β,β-disubstituted styrenes, to yield α-branched amines. In addition, aliphatic alkenes coupled to generate exclusively the anti-Markovnikov hydroamination products.

SUBMITTER: Zhu S 

PROVIDER: S-EPMC3874865 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature