Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease.

ABSTRACT:

Background

Mutations in the nucleotide oligomerization domain-2 (NOD2) gene and positive antibodies to microbial antigens have been found to be associated with the Crohn's disease (CD) phenotype, fibrostenosis. The aim of this study was to confirm these relationships in a large cohort of CD patients and to determine the correlation between the presence of NOD2 variants and antibodies to oligomannan, CBir, outer membrane porin-C (OmpC), and I2 in CD patients with fibrostenosis.

Methods

Sera and DNA from 731 unrelated CD patients were tested for NOD2 variants (SNP 8, 12, and 13) and the antibodies. The results were correlated with CD phenotypes, fibrostenosis, internal penetrating, perianal penetrating, and ulcerative colitis (UC)-like as well as other clinical features.

Re

SUBMITTER: Ippoliti A 

PROVIDER: S-EPMC3875376 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature