Claudin family members exhibit unique temporal and spatial expression boundaries in the chick embryo.

ABSTRACT: The claudin family of proteins are integral components of tight junctions and are responsible for determining the ion specificity and permeability of paracellular transport within epithelial and endothelial cell layers. Several members of the claudin family have been shown to be important during embryonic development and morphogenesis. However, detailed embryonic expression patterns have been described for only a few claudins. Here, we provide a phylogenetic analysis of the chicken claudins and a comprehensive analysis of their mRNA expression profiles. We found that claudin family members exhibit both overlapping and unique expression patterns throughout development. Especially striking were the distinct expression boundaries observed between neural and non-neural ectoderm, as well as wit

SUBMITTER: Collins MM 

PROVIDER: S-EPMC3875640 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature