Ontology highlight
ABSTRACT:
SUBMITTER: Brumatti G
PROVIDER: S-EPMC3875760 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Brumatti Gabriela G Salmanidis Marika M Kok Chung H CH Bilardi Rebecca A RA Sandow Jarrod J JJ Silke Natasha N Mason Kylie K Visser Jolanda J Jabbour Anissa M AM Glaser Stefan P SP Okamoto Toru T Bouillet Philippe P D'Andrea Richard J RJ Ekert Paul G PG
Oncotarget 20131101 11
Deregulated expression of Hox genes such as HoxA9 is associated with development of myeloproliferative disorders and leukemia and indicates a poor prognosis. To investigate the molecular mechanisms by which HoxA9 promotes immortalization of hematopoietic cells, we generated growth factor dependent myeloid cells in which HoxA9 expression is regulated by administration of 4-hydroxy-tamoxifen. Maintenance of HoxA9 overexpression is required for continued cell survival and proliferation, even in the ...[more]