NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals.

ABSTRACT: The microenvironment of cells controls their phenotype, and thereby the architecture of the emerging multicellular structure or tissue. We have reported more than a dozen microenvironmental factors whose signaling must be integrated in order to effect an organized, functional tissue morphology. However, the factors that prevent integration of signaling pathways that merge form and function are still largely unknown. We have identified nuclear factor kappa B (NFkB) as a transcriptional regulator that disrupts important microenvironmental cues necessary for tissue organization. We compared the gene expression of organized and disorganized epithelial cells of the HMT-3522 breast cancer progression series: the non-malignant S1 cells that form polarized spheres ('acini'), the malignant T4-2 cel

SUBMITTER: Becker-Weimann S 

PROVIDER: S-EPMC3875766 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature