Genome-wide high resolution parental-specific DNA and histone methylation maps uncover patterns of imprinting regulation in maize.

ABSTRACT: Genetic imprinting is a specific epigenetic phenomenon in which a subset of genes is expressed depending on their parent-of-origin. Two types of chromatin modifications, DNA methylation and histone modification, are generally believed to be involved in the regulation of imprinting. However, the genome-wide correlation between allele-specific chromatin modifications and imprinted gene expression in maize remains elusive. Here we report genome-wide high resolution allele-specific maps of DNA methylation and histone H3 lysine 27 trimethylation (H3K27me3) in maize endosperm. For DNA methylation, thousands of parent-of-origin dependent differentially methylated regions (pDMRs) were identified. All pDMRs were uniformly paternally hypermethylated and maternally hypomethylated. We also identified

SUBMITTER: Zhang M 

PROVIDER: S-EPMC3875858 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature