Identification of a protein biomarker unique to the pandemic O3:K6 clone of Vibrio parahaemolyticus.

ABSTRACT: The present method of characterizing Vibrio parahaemolyticus strains involves serotyping or detection methods based on assessment of the presence or absence of genes thought to be markers of an organism's pathogenicity. It is unclear whether these assays detect all pathogenic V. parahaemolyticus strains since a clear correlation between the presence of a particular gene and the organism's pathogenicity has not yet been observed. We have described a proteomics-based method to distinguish individual V. parahaemolyticus strains on the basis of their protein profiles and identified a specific protein that is characteristic of the pandemic O3:K6 strain and its clonal derivatives. In the pandemic clone of V. parahaemolyticus, a histone-like DNA-binding protein, HU-alpha, has a C-terminal amino a

SUBMITTER: Williams TL 

PROVIDER: S-EPMC387615 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature