Comorbidity clusters in autism spectrum disorders: an electronic health record time-series analysis.

ABSTRACT:

Objective

The distinct trajectories of patients with autism spectrum disorders (ASDs) have not been extensively studied, particularly regarding clinical manifestations beyond the neurobehavioral criteria from the Diagnostic and Statistical Manual of Mental Disorders. The objective of this study was to investigate the patterns of co-occurrence of medical comorbidities in ASDs.

Methods

International Classification of Diseases, Ninth Revision codes from patients aged at least 15 years and a diagnosis of ASD were obtained from electronic medical records. These codes were aggregated by using phenotype-wide association studies categories and processed into 1350-dimensional vectors describing the counts of the most common categories in 6-month blocks between the ages of 0 to 15. Hi

SUBMITTER: Doshi-Velez F 

PROVIDER: S-EPMC3876178 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature