Segregation of family A G protein-coupled receptor protomers in the plasma membrane.

ABSTRACT: G protein-coupled receptors (GPCRs) transduce many important physiological signals and are targets for a large fraction of therapeutic drugs. Members of the largest family of GPCRs (family A) are thought to self-associate as dimers and higher-order oligomers, although the significance of such quaternary structures for signaling or receptor trafficking is known for only a few examples. One outstanding question is the physical stability of family A oligomers in cell membranes. Stable oligomers would be expected to move through cellular compartments and membrane domains as intact groups of protomers. Here, we test this prediction by recruiting subsets of affinity-tagged family A protomers into artificial microdomains on the surface of living cells and asking if untagged protomers move into th

SUBMITTER: Gavalas A 

PROVIDER: S-EPMC3876820 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature