Impulse conduction increases mitochondrial transport in adult mammalian peripheral nerves in vivo.

ABSTRACT: Matching energy supply and demand is critical in the bioenergetic homeostasis of all cells. This is a special problem in neurons where high levels of energy expenditure may occur at sites remote from the cell body, given the remarkable length of axons and enormous variability of impulse activity over time. Positioning mitochondria at areas with high energy requirements is an essential solution to this problem, but it is not known how this is related to impulse conduction in vivo. Therefore, to study mitochondrial trafficking along resting and electrically active adult axons in vivo, confocal imaging of saphenous nerves in anaesthetised mice was combined with electrical and pharmacological stimulation of myelinated and unmyelinated axons, respectively. We show that low frequency activity in

SUBMITTER: Sajic M 

PROVIDER: S-EPMC3876979 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature