The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB.

ABSTRACT: Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain of VosA is a novel DNA-binding motif that specifically recognizes an 11-nucleotide consensus sequence consisting of two motifs in the promoters of key developmental regulatory genes. The crystal structure analysis of the VosA velvet domain revealed an unforeseen structural similarity with the Rel homology domain (RHD) of the mammalian transcription factor NF-κB. Based on this structural similarity several conserved amino acid residues present in all velvet domains have been ide

SUBMITTER: Ahmed YL 

PROVIDER: S-EPMC3876986 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature