Gene expression and functional annotation of the human and mouse choroid plexus epithelium.

ABSTRACT:

Background

The choroid plexus epithelium (CPE) is a lobed neuro-epithelial structure that forms the outer blood-brain barrier. The CPE protrudes into the brain ventricles and produces the cerebrospinal fluid (CSF), which is crucial for brain homeostasis. Malfunction of the CPE is possibly implicated in disorders like Alzheimer disease, hydrocephalus or glaucoma. To study human genetic diseases and potential new therapies, mouse models are widely used. This requires a detailed knowledge of similarities and differences in gene expression and functional annotation between the species. The aim of this study is to analyze and compare gene expression and functional annotation of healthy human and mouse CPE.

Methods

We performed 44k Agilent microarray hybridizations with RNA derive

SUBMITTER: Janssen SF 

PROVIDER: S-EPMC3877019 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature