Late replication domains are evolutionary conserved in the Drosophila genome.

ABSTRACT: Drosophila chromosomes are organized into distinct domains differing in their predominant chromatin composition, replication timing and evolutionary conservation. We show on a genome-wide level that genes whose order has remained unaltered across 9 Drosophila species display late replication timing and frequently map to the regions of repressive chromatin. This observation is consistent with the existence of extensive domains of repressive chromatin that replicate extremely late and have conserved gene order in the Drosophila genome. We suggest that such repressive chromatin domains correspond to a handful of regions that complete replication at the very end of S phase. We further demonstrate that the order of genes in these regions is rarely altered in evolution. Substantial proportion of

SUBMITTER: Andreyenkova NG 

PROVIDER: S-EPMC3877026 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature