Cadherin-11 mediates contact inhibition of locomotion during Xenopus neural crest cell migration.

ABSTRACT: Collective cell migration is an essential feature both in embryonic development and cancer progression. The molecular mechanisms of these coordinated directional cell movements still need to be elucidated. The migration of cranial neural crest (CNC) cells during embryogenesis is an excellent model for collective cell migration in vivo. These highly motile and multipotent cells migrate directionally on defined routes throughout the embryo. Interestingly, local cell-cell interactions seem to be the key force for directionality. CNC cells can change their migration direction by a repulsive cell response called contact inhibition of locomotion (CIL). Cell protrusions collapse upon homotypic cell-cell contact and internal repolarization leads to formation of new protrusions toward cell-free reg

SUBMITTER: Becker SF 

PROVIDER: S-EPMC3877381 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature