ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma.

ABSTRACT: The vast majority of cancer-related deaths are attributable to metastasis. Effective treatment of metastatic disease will be improved by a better understanding of the molecular mechanisms contributing to this phenomenon. Much of the work in this field has focused on metastasis of carcinomas, tumors of epithelial origin, while metastasis of sarcomas, tumors of mesenchymal origin, remains poorly understood. Experimental evidence from studies in carcinomas, coupled with clinical observations, highlights the importance of both epithelial and mesenchymal characteristics in these cancer cells that make them competent for metastasis. We set out to test if similar cellular plasticity contributes to sarcoma metastasis. We found that the transcription factor, ZEB2, repressed epithelial gene expressi

SUBMITTER: Wiles ET 

PROVIDER: S-EPMC3877663 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature