Fungal gene expression levels do not display a common mode of distribution.

ABSTRACT:

Background

RNA-seq studies in metazoa have revealed a distinct, double-peaked (bimodal) distribution of gene expression independent of species and cell type. However, two studies in filamentous fungi yielded conflicting results, with a bimodal distribution in Pyronema confluens and varying distributions in Sordaria macrospora. To obtain a broader overview of global gene expression distributions in fungi, an additional 60 publicly available RNA-seq data sets from six ascomycetes and one basidiomycete were analyzed with respect to gene expression distributions.

Results

Clustering of normalized, log2-transformed gene expression levels for each RNA-seq data set yielded distributions with one to five peaks. When only major peaks comprising at least 15% of all analyzed genes were

SUBMITTER: Nowrousian M 

PROVIDER: S-EPMC3877863 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature