Detecting cellular reprogramming determinants by differential stability analysis of gene regulatory networks.

ABSTRACT:

Background

Cellular differentiation and reprogramming are processes that are carefully orchestrated by the activation and repression of specific sets of genes. An increasing amount of experimental results show that despite the large number of genes participating in transcriptional programs of cellular phenotypes, only few key genes, which are coined here as reprogramming determinants, are required to be directly perturbed in order to induce cellular reprogramming. However, identification of reprogramming determinants still remains a combinatorial problem, and the state-of-art methods addressing this issue rests on exhaustive experimentation or prior knowledge to narrow down the list of candidates.

Results

Here we present a computational method, without any preliminary select

SUBMITTER: Crespo I 

PROVIDER: S-EPMC3878265 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature