Selective knockout of the casein kinase 2 in d1 medium spiny neurons controls dopaminergic function.

ABSTRACT:

Background

Dopamine, crucial for the regulation of motor function and reward, acts through receptors mainly expressed in striatum as well as cortex. Dysregulation of dopaminergic signaling is associated with various neuropsychiatric disorders. Consequently, dopamine-regulating drugs are effectively used in treating these disorders, such as L-DOPA for Parkinson's disease, methylphenidate for attention-deficit/hyperactivity disorder, or antipsychotics for schizophrenia. As a result, there has been much interest in dissecting signaling networks in the two morphologically indistinguishable D1- and D2-receptor-expressing medium spiny neurons. Our previous results highlighted a role for casein kinase 2 (CK2) in the modulation of dopamine D1 receptor (D1R) signaling in cells.

Methods</

SUBMITTER: Rebholz H 

PROVIDER: S-EPMC3878430 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature