The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro.

ABSTRACT:

Background

In the mammary gland, local recruitment and action of macrophages is a key immunological defence mechanism against infection. Macrophages are members of the innate immune system, serve as the first line of the defence against invading pathogens and are critical effectors and regulators of inflammation. We have examined the early phase response of bovine macrophages to infection with live Staphylococcus aureus. Genome-wide transcript profiling of blood monocyte-derived macrophages from six Norwegian Red heifers infected with live S. aureus for 2 and 6 hours in vitro was performed.

Results

About 420 of the 17 000 genes on the ARK-Genomics bovine cDNA array were differentially regulated at 6 hours post infection. Approximately 70% of the responding genes had a known

SUBMITTER: Lewandowska-Sabat AM 

PROVIDER: S-EPMC3878444 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature