Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation.

ABSTRACT:

Background & aims

IL28B single nucleotide polymorphisms are strongly associated with spontaneous HCV clearance and treatment response in non-transplant populations. A DDX58 single nucleotide polymorphism is associated with the antiviral response of innate lymphocytes. We aimed at evaluating the associations of donor and recipient IL28B (rs12979860 and rs8099917) and DDX58 (rs10813831) genotypes with severity of HCV recurrence after liver transplantation.

Methods

In a case-control study of 523 liver transplantation recipients with HCV, we matched severe with mild recurrent HCV based on 2-year clinical and histologic follow-up. A total of 440 liver transplantation recipients (severe, n=235; mild, n=205) with recipient DNA and 225 (severe, n=123; mild, n=102) with both recipien

SUBMITTER: Biggins SW 

PROVIDER: S-EPMC3878646 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature