Establishing an osteosarcoma associated protein-protein interaction network to explore the pathogenesis of osteosarcoma.

ABSTRACT:

Background

The aim of this study was to establish an osteosarcoma (OS) associated protein-protein interaction network and explore the pathogenesis of osteosarcoma.

Methods

The gene expression profile GSE9508 was downloaded from the Gene Expression Omnibus database, including five samples of non-malignant bone (the control), seven samples for non-metastatic patients (six of which were analyzed in duplicate), and 11 samples for metastatic patients (10 of which were analyzed in duplicate). Differentially expressed genes (DEGs) between osteosarcoma and control samples were identified by packages in R with the threshold of |logFC (fold change)| > 1 and false discovery rate < 0.05. Osprey software was used to construct the interaction network of DEGs, and genes at protein-protein

SUBMITTER: Deng BY 

PROVIDER: S-EPMC3878683 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature