New combined serum creatinine and cystatin C quadratic formula for GFR assessment in children.

ABSTRACT:

Background and objectives

The estimated GFR (eGFR) is important in clinical practice. To find the best formula for eGFR, this study assessed the best model of correlation between sinistrin clearance (iGFR) and the solely or combined cystatin C (CysC)- and serum creatinine (SCreat)-derived models. It also evaluated the accuracy of the combined Schwartz formula across all GFR levels.

Design, setting, participants, & measurements

Two hundred thirty-eight iGFRs performed between January 2012 and April 2013 for 238 children were analyzed. Regression techniques were used to fit the different equations used for eGFR (i.e., logarithmic, inverse, linear, and quadratic). The performance of each model was evaluated using the Cohen κ correlation coefficient and the percentage reaching 3

SUBMITTER: Chehade H 

PROVIDER: S-EPMC3878689 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature