Generalization of associations of kidney-related genetic loci to American Indians.

ABSTRACT:

Background and objectives

CKD disproportionally affects American Indians, who similar to other populations, show genetic susceptibility to kidney outcomes. Recent studies have identified several loci associated with kidney traits, but their relevance in American Indians is unknown.

Design, setting, participants, & measurements

This study used data from a large, family-based genetic study of American Indians (the Strong Heart Family Study), which includes 94 multigenerational families enrolled from communities located in Oklahoma, the Dakotas, and Arizona. Individuals were recruited from the Strong Heart Study, a population-based study of cardiovascular disease in American Indians. This study selected 25 single nucleotide polymorphisms in 23 loci identified from recently publ

SUBMITTER: Franceschini N 

PROVIDER: S-EPMC3878690 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature