A genome wide study of genetic adaptation to high altitude in feral Andean Horses of the paramo.

ABSTRACT:

Background

Life at high altitude results in physiological and metabolic challenges that put strong evolutionary pressure on performance due to oxidative stress, UV radiation and other factors dependent on the natural history of the species. To look for genes involved in altitude adaptation in a large herbivore, this study explored genome differentiation between a feral population of Andean horses introduced by the Spanish in the 1500s to the high Andes and their Iberian breed relatives.

Results

Using allelic genetic models and Fst analyses of ~50 K single nucleotide polymorphisms (SNPs) across the horse genome, 131 candidate genes for altitude adaptation were revealed (Bonferoni of p ≤ 2 × 10(-7)). Significant signals included the EPAS1 in the hypoxia-induction-pathway (HIF)

SUBMITTER: Hendrickson SL 

PROVIDER: S-EPMC3878729 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature