Association between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis.

ABSTRACT:

Background

Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERCC2 rs1799793 and rs13181 polymorphisms with oral cancer risks.

Methods

We retrieved the relevant articles from PubMed and Embase databases. Studies were selected using specific criteria. ORs and 95% CIs were calculated to assess the association. All analyses were performed using the Stata software.

Results

Six studies were included in this meta-analysis. There were no significant associations between ERCC2 rs1799793 and rs13181 polymorphism with overall

SUBMITTER: Zhang E 

PROVIDER: S-EPMC3878799 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature