A call to arms: on refining Plasmodium vivax microsatellite marker panels for comparing global diversity.

ABSTRACT:

Background

Microsatellite (MS) markers have become an important tool for studying the population diversity, evolutionary history and multiplicity of infection (MOI) of malaria parasite infections. MS are typically selected on the basis of being highly polymorphic. However, it is known that the polymorphic potential (mutability) of each marker can vary as much as two orders of magnitude, which radically changes how diversity is represented in the genome from one marker to the next. Over the past decade, approximately 240 Plasmodium vivax MS have been published, comprising nine major panels of markers. Inconsistent usage of each panel has resulted in a surfeit of descriptive genetic diversity data that are largely incomparable between populations. The objective of this study was to s

SUBMITTER: Sutton PL 

PROVIDER: S-EPMC3878832 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature