Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia.

ABSTRACT:

Objective

The chromosomal region, 15q13-q14, including the α7 nicotinic acetylcholine receptor gene, CHRNA7, is a replicated region for schizophrenia. This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7.

Methods

Family-based and case-control association studies were performed on Caucasian-non-Hispanic and African-American individuals from 120 families as well as 468 individual patients with schizophrenia and 144 well-characterized controls. Single-nucleotide polymorphism (SNP) markers were genotyped, and association analyses carried out for the outcomes of schizophrenia, smoking, and smoking in schizophrenia.

Results

Three genes were associated with schizophrenia in both ethnic populations: TRPM1, KLF13, and RYR3. Two SNP

SUBMITTER: Stephens SH 

PROVIDER: S-EPMC3878876 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature